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Sunday sees the inaugural Wear-Tyne derby since 2024, but which side will celebrate – Sunderland or Newcastle?
"For most of last season, you couldn't have imagined Sunderland getting promoted and holding their own with Eddie Howe's Newcastle, never mind being above them in the table," remarked analyst Chris Sutton.
"It is very different now, and the way Sunderland play makes me think they've got a solid shot."
The analyst is providing scoreline guesses for all 380 Premier League games this campaign, in competition with artificial intelligence, the public and a variety of guests.
For this weekend's fixtures, he takes on England Gaming star Daniel 'Stingray' Ray.
Ray is competing for honours for the eLions – the Football Association's official esports team – at the football simulation Uefa eEuro 2025 finals tournament, which will occur at Twickenham Stadium on Saturday.
Viewers can catch Uefa's YouTube, Instagram Live and short-form video channels, as well as EA Sports FC Twitch and YouTube and the national team's Twitch.
What are your thoughts with their scores? You can make your own predictions below.
The most popular scoreline chosen for each game is displayed on the scoreboards at the bottom of this page.
A correct result (choosing a win, draw or defeat) is worth 10 points. A perfect prediction earns 40 points.
Ray, who represents his club side and the Premier League champions as well as England, is entering the fray at the eEuros finals after passing the qualification rounds.
A group of eight will play for their countries at the finals in a knockout format, vying for a $100,000 prize pool and a prestigious spot in the global championship qualifiers, with the Danish representative Anders Vejrgang defending the title he won last year.
"I am feeling really good for it," Ray remarked. "I have a really good coach by my side and preparation has been going well.
"Representing your country is always an honour to play for your country. Of course when you are younger, you dream about doing it as an professional footballer, but when you go into this field and there is an chance to represent England, putting the shirt on is something unique.
"I beat Vejrgang 9-4 in qualifying to get here. I've played against him recently just in practice, and in other tournaments before - but I'd always lost to him in a tournament before.
"In my opinion he is the number one in the world so beating him in a tournament like this just delivers a crazy boost of confidence."
Premier League Weekend Preview
Saturday, 13 December
Chelsea vs Everton
Stamford Bridge, 15:00 GMT
The Blues were excellent against the Gunners at the end of November, when they secured a point after being reduced to 10 men, and I was thinking here we go, they could potentially be challengers for the crown.
Since then, however, they were outfought by Leeds, looked flat against Bournemouth and this week got defeated by Atalanta in the Champions League.
So manager Enzo Maresca really needs a win here to restore momentum, but it won't be easy because the Toffees are such a potent team.
Their key midfielders are playing at the top of their game and they have got a bit of a positive run at the moment.
Based on recent performances you would probably back Everton, while the most sensible prediction would likely be a draw, but I'm throwing caution to the wind.
The Blues have failed to given me any good cause to back them recently, but I just have a hunch they will emerge victorious because they are at home and they are due a win.
Sutton's prediction: 2-1
Stingray's prediction: With this being at the Bridge, I am going to back Chelsea. I think they will start off really well and go 2-0 up, then Everton will nick one back but then Chelsea score late. 3-1
AI's prediction: 2-0
Liverpool vs Brighton
Anfield, 15:00 GMT
I'm attending this game and it will be fascinating to see what we get from the Reds.
I was delighted for Reds boss Arne Slot to get such a crucial result at Inter Milan on Tuesday following all the controversy with Mohamed Salah this week.
Slot ought not to put up with that distraction. I know Salah has been a great for Liverpool but fundamentally Slot just wants to win games and there is no bias in his team selection.
Liverpool changed their tactical setup against Inter and went with a midfield diamond formation and two up top.
All the talk is going to be talking about whether Salah is selected for this game, but the only way he is going to be brought back into the fold is if he makes amends.
Slot's attention will be on winning this game, but it is a tough one.
You could argue it is the same for most teams but I find Brighton so mercurial. I always feel they have got a goal in them, but they are quite open too.
Liverpool need to get back to stringing wins together, but I am not sure how much their efforts at the San Siro will have drained them.
I put a couple of Brighton players in my Fantasy Premier League side, so they will likely do poorly - but I do fancy them to get something at Anfield.
Sutton's prediction: 2-2
Stingray's prediction: This is a game which is going to give Liverpool a bit more of their confidence back. Obviously they had a good win in midweek and they can build more momentum here. 2-1
AI's prediction: 3-1
Sunday, 14 December
Sunderland vs Newcastle
Stadium of Light, 14:00 GMT
The Black Cats have had the opportunity to rest while Newcastle had to battle intensely against Bayer Leverkusen on Wednesday, only to let their lead slip away late on.
With the exception of their brilliant performance against Everton a couple of weeks ago, Newcastle's away form has been poor, particularly straight after they've played in the Champions League.
It is anticipated that that trend to continue on Sunday, and their lack of freshness is likely to be a key element in how this game goes because of their rivals' energetic style.
We saw how incessant Regis le Bris's side are. They dominated the Gunners, and it was amazing to watch.
Everyone talks about how Granit Xhaka has been brilliant for the Black Cats, and he has been excellent, but Noah Sadiki, who plays alongside him, has also been one of the signings of the season and warrants praise too.
All signs point to this being the best game|most exciting fixture